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Canadian Med Center

Linzess Dosage and Administration

Monday 1 April 2024
6 minute(s) read

Table of Contents

I. Linzess Dosages

II. How to Take Linzess

III. Missing a Linzess Dose

IV. How to Store Linzess

V. Conclusion

Constipation can be an uncomfortable and disruptive condition, especially when it becomes chronic. For those with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC), finding an effective treatment is key.

Linzess (linaclotide) is a medication that can provide relief by stimulating the intestines to produce more fluid and accelerate the passage of stool. [1] But to get the most out of Linzess, it's important to take it properly.

In this article, we'll look at the recommended dosages for Linzess based on your condition. We'll also go over some helpful instructions on how to take it, what to do if you miss a dose, and tips for storing it correctly.

Linzess Dosages

When taking Linzess, it's important to work with your doctor to find the right dosage for you. Linzess comes in capsules of 72 mcg, 145 mcg, and 290 mcg. Your doctor will consider several factors when determining which dosage to prescribe, including: [1]

  • The specific condition you're using Linzess to treat. The dosage may vary depending on whether you have irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC).
  • The severity of your symptoms. More severe symptoms may require a higher dosage.
  • How you respond to treatment. Your doctor may start with a lower dosage and increase it over time to evaluate how you respond and minimize side effects. [1]

The goal is to use the smallest Linzess dosage that provides the desired treatment effect. Be sure to take the exact dosage your doctor prescribes and let them know if you have any concerns.

Irritable Bowel Syndrome with Constipation (IBS-C)

The recommended dosage of Linzess for IBS-C is 290 mg once daily. This medication can help make bowel movements easier and more regular. [1]

IBS-C is a specific type of irritable bowel syndrome. With this condition, constipation is the main symptom rather than diarrhea. Constipation means having infrequent bowel movements, typically fewer than three times weekly. Along with constipation, IBS-C also often involves: [2]

  • Bloating and abdominal discomfort
  • Stomach cramps and pain
  • Increased gas and flatulence
  • Mucus in the stool
  • Changes in stool consistency or odor [2]

It's important to understand that IBS-C is different from chronic constipation. While those with chronic constipation have problems having bowel movements, they usually don't experience the abdominal pain and discomfort that people with IBS-C do. [2]

Chronic Idiopathic Constipation

The recommended starting dosage of Linzess for chronic idiopathic constipation (CIC) is 145 mcg, and it is taken once per day. Some people may begin with a lower 72 mcg dose if the 145 mcg causes diarrhea. [1]

Chronic idiopathic constipation is a medical condition where a person experiences ongoing problems with constipation, but doctors can't determine the underlying cause. [3]

Symptoms of CIC can include:

  • Straining to pass stools
  • Passing very hard or lumpy stools
  • Having a feeling of incomplete emptying after a bowel movement
  • Experiencing fewer than three bowel movements per week [3]

Functional Constipation in Children Above Six Years of Age

The recommended dosage of Linzess for children ages 6 and up with functional constipation is 72 mcg taken once daily. [1]

Functional constipation refers to constipation that occurs without any underlying anatomical or medical issues. It is often caused by a combination of factors, such as environment, stress, diet, coping skills, and level of social support. [4]

Some signs your child may have functional constipation include:

  • Infrequent or difficult bowel movements
  • Hard stools that are painful to pass
  • Feeling like they can't fully empty their bowels [4]

How to Take Linzess

applesauce in a wooden bowl

Linzess is a capsule you swallow. Take your daily dose consistently, not just when you feel constipated. Unlike laxatives, which can be used when needed, Linzess works best with daily use. [1]

For the best results, take your Linzess dose on an empty stomach, at least 30 minutes before eating your first meal. If you have trouble swallowing the capsule whole, you can open it and mix the contents into applesauce or water. [1]

Taking Linzess in Applesauce

If swallowing the Linzess capsule whole is difficult, you can mix the capsule contents into room-temperature applesauce. This can make ingesting the medication much easier and more comfortable.

  • Place one teaspoon of room-temperature applesauce into a bowl. Make sure the applesauce is soft enough to mix the capsule contents easily.
  • Carefully open the Linzess capsule over the applesauce. Sprinkle the tiny beads inside the capsule onto the applesauce.
  • Mix the beads into the applesauce thoroughly so they are evenly distributed.
  • Eat the entire applesauce and bead mixture immediately. Do not chew the beads; simply swallow them with the applesauce. It is important to consume the entire dose right away for the best results.
  • Do not save any of the mixture for later. [1]

Taking Linzess in Water

You may find it easier to mix Linzess with water instead of swallowing the intact capsule with water. Here are the steps to take Linzess with water:

  • Pour about 30 mL of room-temperature bottled water into a cup.
  • Open the capsule and sprinkle the beads from the capsule into the water.
  • Gently swirl the beads and water for at least 20 seconds.
  • Immediately swallow the entire mixture of beads and water.
  • Add another 30 mL of water to any remaining beads in the cup, swirl for 20 seconds, and swallow right away.
  • Do not save any of the mixture for later. [1]

The medication is coated on the outside of the beads. It will dissolve into the water while the beads remain visible and intact. You do not have to swallow all the beads to get the full dose. [1]

Missing a Linzess Dose

If you miss a dose of Linzess, skip the missed dose and continue with your regular dosing schedule. Avoid doubling up on doses to compensate for the missed one. [1]

Linzess works best when taken every day as prescribed by your doctor. If you stop taking Linzess, your constipation symptoms can return within a week. Linzess is not meant to be used as needed, like some over-the-counter laxatives. Take it daily as directed to get the most benefit from Linzess and avoid a return of symptoms. [5]

How to Store Linzess

a pharmacist explaining how to store medication

When taking Linzess, it's important to store it correctly to maintain its effectiveness. Here are some tips for proper storage:

  • Keep the medication in a secure place that is out of reach of children and pets. Accidental ingestion can be dangerous.
  • Store Linzess at room temperature, around 25°C or 77°F. Don't store it somewhere too hot or cold.
  • Keep the medicine in its original prescription container. This helps protect the pills from moisture that could cause them to break down.
  • Make sure to keep the container tightly closed when not in use. This also prevents moisture from getting in.
  • Don't throw away the desiccant packet in the bottle. This packet absorbs moisture and keeps the pills dry.
  • Check the expiration date and dispose of any unused Linzess after this date. Expired medicine may not work as well. [5]


When used correctly, Linzess can be an effective treatment for different types of constipation. It's essential to take Linzess exactly as your doctor prescribes and follow the dosing instructions carefully. This includes taking the correct dose for your condition, administering it properly (with water before eating in the morning), and knowing what to do if you miss a dose. Proper storage is also vital in maintaining the medication's potency.

To learn more about this medication, visit our Linzess blog for more topics.

The content in this article is intended for informational purposes only. This website does not provide medical advice. In all circumstances, you should always seek the advice of your physician and/or other qualified health professionals(s) for drug, medical condition, or treatment advice. The content provided on this website is not a substitute for professional medical advice, diagnosis, or treatment.