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What is Domperidone?

In addition to being the active ingredient in Motilium, domperidone is also the name of the generic version. Domperidone belongs to the drug class called dopamine antagonists. It improves symptoms of nausea and vomiting by blocking the chemical messengers in the brain that cause these symptoms. Domperidone also increases intestinal movement and bowel contractions to improve symptoms of gastroparesis.

Gastroparesis is a condition that affects motility, which is the spontaneous stomach muscle movement responsible for moving food through the digestive tract. Patients with gastroparesis often experience abdominal pain, bloating, acid reflux, and a reduced appetite. Gastroparesis may also cause changes in blood sugar levels, weight loss, and even malnutrition. In addition to diet changes, your doctor may prescribe domperidone to manage symptoms.

What is Motilium?

Motilium is a brand-name prescription medicine used to treat gastroparesis, a condition characterized by a slow-moving stomach. Motilium is also approved to treat symptoms of nausea and vomiting. Motilium contains the active ingredient domperidone. This medication works by increasing stomach contractions to move food through the intestines. Motilium use should be supervised by your doctor. This medication is not approved for use in children.

Along with treating gastroparesis symptoms, domperidone may also be used to treat side effects caused by drugs used to treat Parkinson’s disease. Parkinson’s disease is a brain disorder that causes symptoms of stiffness, shakiness, and impaired coordination. The medications used to manage these symptoms may cause nausea, vomiting, low blood pressure, and confusion. Domperidone may be prescribed alongside certain medications for Parkinson’s disease to alleviate nausea and vomiting.

Domperidone Dosage

Brand-name Motilium and generic domperidone is available on Canadian Med Center in 10 mg tablets. How many tablets you take will depend on your condition and its severity. Generally, the recommended dosage for adults with gastroparesis is one 10 mg tablet, three to four times a day. However, patients with more severe motility problems may require two tablets up to four times a day. To treat symptoms of nausea and vomiting, your doctor will likely prescribe two tablets (total of 20 mg), three to four times daily.

Domperidone Side Effects

Domperidone may cause several mild side effects that typically do not need medical attention. These side effects include hot flashes, skin itchiness, pain or swelling in the eyes, and dry mouth. Other common side effects of domperidone include:

  • Breast swelling in men
  • Irregular menstrual periods in women
  • Increased lactation from the nipple
  • Headache
  • Breast pain

While taking Motilium, it is essential that you attend regular visits to your doctor. If you take too much domperidone, you may experience signs of an overdose. You may need emergency help if you experience:

  • Irregular heartbeat
  • Fainting
  • Loss of balance
  • Loss of muscle control
  • Disorientation
  • Difficulty speaking

Although this medication comes with risks, serious side effects are rare, and studies show that domperidone is well-tolerated and can significantly improve the quality of life in gastroparesis patients. Speak to your doctor for a complete list of domperidone side effects.

Domperidone Interactions

Certain contraindicated medications should not be taken with domperidone. Doing so increases the risk of adverse effects and severe complications. However, certain exceptions exist, and you may be prescribed a contraindicated drug despite the risk of an interaction. Your doctor will determine whether the benefits outweigh the risks of combining treatments. Generally, domperidone should not be taken with:

  • Antihistamines
  • Antipsychotics
  • Antifungals
  • Calcium channel blockers
  • HIV protease inhibitors
  • Macrolide antibiotics
  • Protein kinase inhibitors
  • Pain relievers like fentanyl, hydromorphone, morphine, and oxycodone



Where can I buy domperidone?

Domperidone is available on Canadian Med Center in brand-name and generic versions. Buying domperidone online through a Canadian pharmacy helps you save immensely. Plus, since generic drugs are almost always significantly cheaper than the brand-name, the option of generic domperidone helps you save even more. By using Canadian Med Center, you can expect to save up to 90 percent on your prescriptions.

How long does domperidone stay in your system?

In most patients, domperidone has a half-life of 7 to 9 hours. Essentially, this means that domperidone stays in your system for approximately two days. If you have impaired renal function, domperidone may stay in your system for longer.

How long does domperidone take to work?

On average, domperidone takes about 30 to 60 minutes to begin working. Doctors recommend taking domperidone for the shortest duration at the lowest effective dose to reduce the risk of side effects. Generally, domperidone is prescribed for a week. Always follow your doctor’s directions on how much domperidone you should take and for how long.

How does domperidone work?

Domperidone works by affecting the stomach muscles and blocking certain chemicals in the brain that make you feel nauseous. By doing so, domperidone increases the movement of food through the digestive tract, improving motility.

What is domperidone 10 mg?

Domperidone 10 mg tablets are the recommended starting dose for most patients with gastroparesis. Domperidone 10 mg is typically taken three to four times a day for about a week. If your symptoms are severe, your doctor may increase your dosage to two tablets to combine for 20 mg.

How can I order domperidone from Canada?

Ordering domperidone from Canada is a great way to save time and money. To get your domperidone from Canada today, place your order through Canadian Med Center and have your prescription delivered directly to your door. Join the many Americans who have been safely and securely getting their medications from Canada.

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Esther Mae W

November 4, 2022

Excellent service on setting up our account

Robert G

October 27, 2022

Great service! The pills arrived even faster than I expected.

Stephen D

October 14, 2022

Your operators are always courteous and knowledgeable. Very good service.


October 13, 2022

I've been a Canadian Med Center customer for about 6 years now. In all that time there was never once that I considered taking my business elsewhere. They do a great job and the people they contract with are also super.


October 5, 2022

Cheaper and efficient.

Dorothy Serrie S

October 4, 2022

Always appreciate their prompt service but especially appreciate their hanging in there when there was difficulty getting my doctor to renew my prescription!

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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