Canada Drug Center > Nexium (Esomeprazole) - Also known as Neksium Internationally
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Esomeprazole (Generic)
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100 $108.00 $1.08 BUY
Nexium (Esomeprazole) - Also known as Neksium Internationally
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100 $84.00 $0.84 BUY
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Nexium is a proton pump inhibitor class of drug that helps in reducing the amount of acid produced in the stomach. This drug is used to treat gastro-esophageal reflux disease (GERD) and other pathological hypersecretory conditions including Zollinger-Ellison syndrome. It can also be prescribed for the treatment of dyspepsia, peptic ulcer disease (PUD) and for healing esophagus damage caused due to acid reflux disease. Gastric ulcer caused by non-steroidal anti-inflammatory drugs can also be treated with Nexium. The drug is approved by most of the drug regulatory authorities of the world.


One should follow the given usage instructions while taking Nexium:

  • Nexium tablet should be swallowed whole without biting or chewing with a glass full of water.
  • Esomeprazole must be consumed at least one hour before the meal.
  • Patients should stick to the doctor’s prescribed dosage to maximize the effect of the drug.
  • The drug should be taken at the same time every day.
  • Patients having difficulty in swallowing the capsule can mix the capsule content in water or applesauce to take it easily.
  • Patients should not suddenly stop the medication.


The dosages of Esomeprazole vary for different treatments. The prescribed Nexium dosages for different diseases include:

GERD – GERD patients are advised with 20 mg or 40 mg of Nexium taken once in a day for 4 to 8 weeks. Children between the age group of 1 to 11 years are prescribed the dosage of 10 mg to 20 mg taken once in a day for up to 8 weeks. Intestinal Ulcers - The recommended adult dose is 40 mg taken once in a day for the intestinal ulcers patients (caused by H. pylori). The patients have to take 1,000 mg amoxicillin and 500 Mg clarithromycin along with Nexium. Stomach Ulcers – For treating stomach ulcers patients are given 20 mg or 40 mg of Nexium once in a day for up to 6 months. Zollinger-Ellison Syndrome–Patients are advised with a dosage of 40 mg taken twice in a day.

Missed Dose and Overdose of Nexium

Missed Does

If a dose of Nexium is missed, the patients can take the missed dose as soon as they remember it. However, patients should not take the missed does if it is time for the next dose. Patients should not take double or extra does to compensate for the missed does.

Overdoes of Nexium

Overdose victims may suffer from headache, nausea, drowsiness, confusion, blurred vision, fast heartbeat, dry mouth, sweating, shortness of breath, seizure, tremor, tachycardia, loss of coordination, diaphoresis, or flushing. The patients should be immediately provided with medical attention. One can also seek advice from their local poison helpline.

Storage Instructions

Nexium must be stored in a cool, dry place and at room temperature between 20°C to 25°C (68°F to 77°F). The container of Nexium should be closed tightly and kept out of the reach of children. Expired and unused medications must be safely disposed.


Patients prescribed with Esomeprazole must be aware of the following warnings:

  • The intake of Nexium in high doses for more than a year may increase the risk of fracture in the hip bone, spine or wrist.
  • Hypomagnesemia or loss of magnesium in the body may occur in patients taking Esomeprazole for long-term.
  • The risk of severe inflammation of the stomach lining may increase in the patients using Nexium for a long period.
  • Pregnant women should avoid using Esomeprazole because the effect of the medicine on an unborn baby is unknown.
  • Nexium may increase the risk of severe diarrhea associated with intestinal infections.
Side Effects

Esomeprazole has proved its effectiveness in the treatment of acid reflux disease. There are few side effects associated with taking this drug. However, patients can consult the doctor if any of the side effects becomes bothersome. Side effects that may occur include:

Common Side Effects of Esomeprazole

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Constipation
  • Drowsiness
  • Dry Mouth

Severe Side Effects:

  • Seizures
  • Dizziness
  • Abnormal or fast heartbeat
  • Jitteriness
  • Tremors
  • Spasms
  • Weakness
  • Cramps or muscle ache
  • Spasm of the voice box

Drug Interactions

Esomeprazole may interact with other medicines and affect their mechanism. Patients must inform their doctor about all the prescription and non-prescription medications that they are taking. It is vital for the patients to make sure that the combination of drug they are using is safe. Nexium can have interactions with the following drugs:

  • Cilostazol (Pletal)
  • Diazepam (Valium)
  • Tacrolimus (Prograf)
  • Erlotinib (Tarceva)
  • Methotrexate
  • Clopidogrel (Plavix)
  • Nelfinavir (Viracept)
  • Saquinavir (Fortovase)
  • Products that contain iron
  • Digoxin (Lanoxin)
  • St.John’s Wort (Hypericum perforatum)
  • Rifampin (Rimactane, Rifater, Rifamate)
  • Warfarin (Coumadin, Jantoven)
  • Ketoconazole (Nizoral)
  • Voriconazole (Vfend)
  • Atazanavir (Reyataz)
IMPORTANT NOTE: The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.
IMPORTANT NOTE: Please note that not all medications, including any referenced on this page, are dispensed from our affiliated Canadian pharmacy. The medications in your order may be filled and shipped from an approved International fulfillment center located in a country other than Canada. In addition to dispensing medications from our Canadian pharmacy, medication orders are also filled and shipped from international fulfillment centers that are approved by the regulatory bodies from their respective countries. Medication orders are filled and shipped from approved fulfillment centers around the world including, but not limited to, Canada, Singapore, United Kingdom, New Zealand, Turkey, Mauritius, India, Australia, and the United States. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries including, but not limited to, Canada, United Kingdom, New Zealand, Turkey, India, Australia, and the United States. All of our affiliated fulfillment centers have been approved by the regulatory bodies from their respective countries.

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What's the difference between generic drugs and brand name drugs?

What's the difference between the branded products you sell and the ones I get locally?
The branded drugs we sell are chemically and therapeutically no different from the ones you get in your local pharmacy. They both generally come from the same exact manufacturer. Generally, the main difference* is in the packaging and the price. Our packaging may be different from what you get locally, but we're also much cheaper.

* Other differences may include differences in trade name, form, and general appearance.

Why are there packaging differences?
Due to differences in government regulation, different countries have different packaging requirements. For example, a product in Canada (or any other country) will have different packaging than the same product in the US even though both drugs are chemically and therapeutically equivalent and are generally manufactured by the same exact company.

Why are your drugs so much cheaper?
Due to government price controls, medications from Canada and many other countries are often significantly cheaper than in the United States. Also, other countries may have more affordable generic versions of drugs, which may not yet be available in the US.

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