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Premarin (Conjugated Estrogens; a mixture of estrogen hormones) are used to treat hot flushes (hot flashes; sudden strong feelings of heat and sweating) and/or vaginal dryness, itching, and burning in women who are experiencing menopause (change of life; the end of monthly menstrual periods). Estrogen is a female sex hormone produced by the ovaries. Estrogen pills are necessary for many processes in the body. Premarin is also used to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.
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Take Premarin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Premarin is sometimes taken on a daily basis. For certain conditions, the medicine is given in a cycle, such as 3 weeks on followed by 1 week off. Follow your doctor's instructions.
If you see what looks like part of a conjugated estrogen tablet in your stool, talk with your doctor.
Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.
If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Premarin.
You should not use Premarin if you have:
unusual vaginal bleeding that has not been checked by a doctor;
a history of heart attack, stroke, or blood clot;
an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or
a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use Premarin if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Premarin may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using Premarin, to help lower this risk. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estrogen should not be used to prevent heart disease, stroke, or dementia. This medicine may actually increase your risk of developing these conditions.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
a thyroid disorder; or
high levels of calcium in your blood
This is not a full list of conditions, consult your doctor or pharmacist if you have any questions.
Common estrogen side effects include:
If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Tell your doctor promptly if you see the tablet in your stool.
Tell your doctor right away if you have any serious Premarin side effects, including:
This medication may rarely cause serious problems from blood clots (such as heart attacks, strokes, DVT, PE)
Get medical help right away if you have any serious side effects of Premarin including:
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Q: Why are Premarin tablets prescribed?
A: This medication is a female hormone used to aid in reducing symptoms of menopause.
Q: What other medications are known to interact with Premarin tablets?
A: Many drugs can interact with Premarin, it is important to discuss all OTC and herbal products you are taking with your doctor.
Q: Is there anything I should avoid while on this medication?
A: Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using conjugated estrogens. Also, avoid the use of grapefruit products including grapefruit juice.
Q: How should I store this medication?
A: Store Premarin tablets at room temperature away from moisture, heat, and light.