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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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How much does Premarin cost?

Buying Premarin online with Canadian Med Center is the perfect way to make big savings on the cost of your medications. Premarin is available in 0.3mg, 0.625mg and 1.25mg strengths. The price of Premarin depends on the strength you are purchasing.

What is Premarin?

Premarin (Conjugated Estrogens; a mixture of estrogen hormones) are used to treat hot flushes (hot flashes; sudden strong feelings of heat and sweating) and/or vaginal dryness, itching, and burning in women who are experiencing menopause (change of life; the end of monthly menstrual periods). Estrogen is a female sex hormone produced by the ovaries. Estrogen pills are necessary for many processes in the body. Premarin is also used to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.

Looking for a Premarin coupon?

You can save up to 90% if you buy Premarin online with Canada Drug Center. You don't need a Premarin coupon to get our great prices.

Take Premarin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Premarin is sometimes taken on a daily basis. For certain conditions, the medicine is given in a cycle, such as 3 weeks on followed by 1 week off. Follow your doctor's instructions.

If you see what looks like part of a conjugated estrogen tablet in your stool, talk with your doctor.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.

If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Premarin.


You should not use Premarin if you have:

  • unusual vaginal bleeding that has not been checked by a doctor;

  • liver disease;

  • a history of heart attack, stroke, or blood clot;

  • an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or

  • a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.

Do not use Premarin if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Premarin may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using Premarin, to help lower this risk. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Estrogen should not be used to prevent heart disease, stroke, or dementia. This medicine may actually increase your risk of developing these conditions.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • heart disease;

  • liver problems, 

  • kidney disease;

  • a hysterectomy;
  • migraines;

  • porphyria;
  • a thyroid disorder; or

  • high levels of calcium in your blood

This is not a full list of conditions, consult your doctor or pharmacist if you have any questions.

Premarin Side Effects

Common estrogen side effects include:

  • Upset stomach
  • Nausea/vomiting
  • Bloating
  • Headache
  • Breast tenderness
  • Weight changes

If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor promptly if you see the tablet in your stool.

Tell your doctor right away if you have any serious Premarin side effects, including:

  • mental/mood changes (such as depression)  
  • breast lumps
  • unusual vaginal bleeding (such as spotting, prolonged/recurrent bleeding)
  • increased or new vaginal irritation/itching/discharge/odor
  • severe stomach or abdominal pain,
  • persistent nausea/vomiting, yellowing eyes/skin

This medication may rarely cause serious problems from blood clots (such as heart attacks, strokes, DVT, PE) 

Get medical help right away if you have any serious side effects of Premarin including:

  • chest/jaw/left arm pain
  • coughing up blood
  • sudden/severe headache, 
  • weakness on one side of the body, confusion, slurred speech;
  • sudden vision changes (such as partial/complete blindness);
  • pain/redness/swelling of legs;
  • tingling/weakness/numbness in the arms/legs,
  • trouble breathing, sudden dizziness
  • a very serious allergic reaction to this product (including rash, itching/swelling, dizziness, and trouble breathing) 

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.


Q: Why are Premarin tablets prescribed?

A: This medication is a female hormone used to aid in reducing symptoms of menopause. 

Q: What other medications are known to interact with Premarin tablets?

A: Many drugs can interact with Premarin, it is important to discuss all OTC and herbal products you are taking with your doctor. 

Q: Is there anything I should avoid while on this medication?

A: Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using conjugated estrogens. Also, avoid the use of grapefruit products including grapefruit juice. 

Q: How should I store this medication?

A: Store Premarin tablets at room temperature away from moisture, heat, and light.


A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-205-1510 and a member of our CareTeam will be happy to assist you.

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* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

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I was SUPER skeptical and everything went so smoothly. I had about a 3 week wait, but checked back with customer service a few times and they were very quick to respond. Saved a ton of money!
Nancy August 30, 2021

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Prompt, courteous service, friendly reminder calls about refills, easy ordering by phone, and good prices. Has been a very good experience.
Richard July 27, 2021

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The ordering of my medication was very good. Smooth as silk.
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Great customer service.
Ed July 26, 2021

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Always knowledgeable, courteous and helpful. Happy to have their service.
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First time ordering a Rx from your company. Very, very simple procedures and extremely friendly customer service.
Diane July 14, 2021

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Great company, great customer service. Thank you!
Dawn July 14, 2021

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Great experience with service & with product. I could only wish that it didn’t take so long for processing & that payment could be made via credit card or PayPal.
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Thank you.
Rodney April 7, 2021

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The service is always efficient and ordering is easily processed. They always check in with you and keep you informed about your orders progress.
Eric February 24, 2020
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