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What is Rexulti?

Rexulti is the brand name for brexpiprazole, which is a medication primarily used to treat schizophrenia and major depressive disorder (MDD) in adults. It belongs to a class of medications known as atypical antipsychotics.

Rexulti is a prescription medication used to treat:

Schizophrenia: a mental disorder characterized by distorted thinking, hallucinations, and emotional disturbances.

Major Depressive Disorder (MDD): a mood disorder marked by persistent feelings of sadness, hopelessness, and loss of interest or pleasure in activities.

Rexulti typically comes in tablet form, and the dosage varies depending on the condition being treated and the individual's response to the medication. It's usually taken orally, once daily, with or without food. Your doctor will determine the appropriate dosage for you based on your medical condition and response to treatment.

Side Effects of Rexulti

Common side effects of Rexulti may include:

  • Nausea
  • Dizziness
  • Fatigue
  • Headache
  • Weight gain
  • Restlessness
  • Insomnia

Less common but more serious side effects may include:

  • Neuroleptic Malignant Syndrome (NMS): a rare but potentially life-threatening reaction characterized by high fever, muscle rigidity, altered mental status, and autonomic dysfunction.
  • Tardive Dyskinesia: a movement disorder characterized by involuntary, repetitive movements of the face, tongue, or other body parts.
  • Increased risk of suicidal thoughts or behavior, especially in young adults.

If you experience any severe or persistent side effects, it's important to contact your doctor immediately.

Precautions

Before taking Rexulti, inform your doctor if you have any medical conditions, especially:

  • Liver problems
  • Kidney problems
  • Diabetes
  • Seizures
  • Low white blood cell count
  • History of suicidal thoughts or attempts
  • History of substance abuse

Also, let your doctor know about all the medications you're currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, as some medications may interact with Rexulti.

FAQs

How long does it take for Rexulti to work?

It may take several weeks for Rexulti to start working fully. It's important to continue taking the medication as prescribed, even if you don't notice immediate improvement.

Can Rexulti be taken with other medications?

Rexulti can interact with certain medications, so it's essential to inform your doctor about all medications you're taking before starting Rexulti.

Can Rexulti be used during pregnancy or breastfeeding?

The safety of Rexulti during pregnancy and breastfeeding has not been established. Consult your doctor before taking Rexulti if you are pregnant, planning to become pregnant, or breastfeeding.

Can Rexulti be stopped abruptly?

It's generally not recommended to stop taking Rexulti abruptly without consulting your doctor, as this can lead to withdrawal symptoms or a relapse of your condition. Your doctor can provide guidance on how to safely discontinue the medication if necessary.

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Evelyn L

February 5, 2026

Always excellent help. Always contacts me and reminds me. Always very knowledgeable and kind. Thanks

Larry G

February 5, 2026

The young woman who took my order was courteous and explained cost and shipment completely. As promised, I received email confirmation immediately after our conversation.

Nairy

February 5, 2026

I needed to order refills for the meds and Crystally was very helpful and kind and made it easy to put my refill order… thank you

Judith S

February 4, 2026

Good price & agent for application did an excellent job.

Pam N

February 2, 2026

I appreciate the kind words of the people I have spoken with. Very patient.

Chad S

February 2, 2026

Representatives are all very professional and informative also able to get price reduction for long time customers. Happy with my prescriptions and service.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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