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What is Trintellix and How Does it Work?

Trintellix is an antidepressant medication used to treat major depressive disorder. Unlike many other antidepressants, Trintellix works in a unique way to ease symptoms of depression.

Trintellix belongs to a class of antidepressants known as atypical antidepressants. It affects serotonin levels in the brain differently than selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs).

While the exact mechanism of Trintellix is not fully understood, it is believed to block the reabsorption of serotonin after it is released, leaving more available in the spaces between neurons. This helps enhance communication between neurons and improves mood.

If you're considering Trintellix as a treatment option, affordability is an important factor to consider. Fortunately, you can find affordable Trintellix at reputable online Canadian pharmacies like Canadian Med Center. By ordering from a Canadian pharmacy, you can save up to 90% on this medication.

When starting Trintellix, talking to your doctor about potential drug interactions is key to staying safe and getting the most out of your medication. Trintellix has some important drug interactions to keep in mind.

  • Monoamine oxidase inhibitors (MAOIs): do not take Trintellix within 14 days of stopping an MAOI antidepressant and wait at least 21 days after stopping Trintellix before starting an MAOI. Combining these medications raises the risk of serotonin syndrome, a dangerous condition causing fever, rigid muscles, confusion, and seizures.
  • Serotonergic drugs: Combining Trintellix with other serotonergic medications can also heighten the risk of serotonin syndrome. 
  • CYP2D6 inhibitors: These inhibitors can impede the breakdown of Trintellix, leading to elevated plasma concentrations of the drug. This increases the risk of serotonin syndrome.
  • CYP inducers: These medications can accelerate the breakdown of Trintellix in the body, potentially reducing its effectiveness. 
  • Blood thinners: The combination of Trintellix with blood thinners can elevate the risk of stomach bleeding.

Trintellix Side Effects

Starting Trintellix can be an adjustment period as your body gets used to the medication. Many experience temporary side effects that usually resolve within the first few weeks. It's important to know that these are normal and tend to be mild and manageable. However, contact your doctor right away if any side effects are severe or don't go away.

Common side effects include:

  • Constipation
  • Diarrhea
  • Dry mouth
  • Nausea
  • Vomiting
  • Dizziness
  • Nausea
  • Itching
  • Mild allergic reaction

Trintellix Dosages

Trintellix comes in three strengths:

  • 5 mg tablets
  • 10 mg tablets
  • 20 mg tablets

When starting Trintellix, your doctor will prescribe a low dose and gradually increase it over time until you reach the minimum effective dose that improves your depression symptoms.

The typical starting dosage for major depression is 10 mg once daily, with the option to increase to 20 mg if needed for additional benefit. If you experience any side effects on a higher dose, your doctor may decide to lower your dosage to help minimize discomfort.

The goal is to find the lowest dosage that provides relief for your depression.


What is Trintellix used for?

Trintellix is an antidepressant medication that was approved by the FDA in 2013 to treat major depressive disorder (MDD) in adults.

What if I miss a dose of Trintellix?

If you realize you've forgotten a dose, take it as soon as you remember. But if it's close to your next scheduled dose, it's best to skip the missed one and continue with your regular schedule. Do not double up on the next dose to compensate for the missed one.

How long does it take for Trintellix to work?

It can take time for Trintellix to start working. According to clinical studies, many people experience initial effects within the first two weeks of treatment. However, the full effects typically take around four weeks or longer to develop during daily use.

How do I take Trintellix?

When taking Trintellix, it's important to follow your doctor's instructions. This medication should be taken orally once daily, with or without food. Taking it at the same time each day can help maintain consistent levels in your body.

Real People, Trustworthy Reviews

See what others are saying about their experience!

Esther Mae W

November 4, 2022

Excellent service on setting up our account

Robert G

October 27, 2022

Great service! The pills arrived even faster than I expected.

Stephen D

October 14, 2022

Your operators are always courteous and knowledgeable. Very good service.


October 13, 2022

I've been a Canadian Med Center customer for about 6 years now. In all that time there was never once that I considered taking my business elsewhere. They do a great job and the people they contract with are also super.


October 5, 2022

Cheaper and efficient.

Dorothy Serrie S

October 4, 2022

Always appreciate their prompt service but especially appreciate their hanging in there when there was difficulty getting my doctor to renew my prescription!

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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